ARYL ALKYNAMIDE DERIVATIVES

A compound which is useful as a STING inhibitor is provided. The present inventors have found aryl alkynamide derivatives having an inhibitory action on STING. The aryl alkynamide derivatives of the present invention have an inhibitory action on STING and can be used as an agent for treating an auto...

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Bibliographische Detailangaben
Hauptverfasser:	CIAVARRI, Jeffrey, NEGORO, Kenji, KITAMURA, Kai, SEO, Ryushi, KAKEFUDA, Kenichi, KAMIKAWA, Akio, MAEDA, Junko, YAMASHITA, Yumi, HAMAGUCHI, Wataru, KURIWAKI, Ikumi
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A compound which is useful as a STING inhibitor is provided. The present inventors have found aryl alkynamide derivatives having an inhibitory action on STING. The aryl alkynamide derivatives of the present invention have an inhibitory action on STING and can be used as an agent for treating an autoimmune disease, a neurodegenerative disease, a type I interferonopathy and/or other STING-mediated disease. Un composé qui est utile en tant qu'inhibiteur de STING est décrit. Les présents inventeurs ont trouvé des dérivés d'arylalkynamide ayant une action inhibitrice de STING. Les dérivés d'arylalkynamide de la présente invention ont une action inhibitrice de STING et peuvent être utilisés en tant qu'agent pour le traitement d'une maladie auto-immune, d'une maladie neurodégénérative, d'une interféronopathie de type I et/ou d'une autre maladie médiée par STING.