NOVEL IONIZABLE LIPIDS AND LIPID NANOPARTICLES COMPRISING SAME

The present invention relates to novel ionized lipids and lipid nanoparticle comprising the ionized lipids. A therapeutic agent using the lipid nanoparticles comprising novel-type ionized lipids according to the present invention can minimize in vivo side effects due to components of the nanoparticles, effectively transfer the nanoparticles to target cells, and escapes edosomes in target cells, thereby efficiently transferring a pharmaceutically effective substance, such as a nucleic acid, to the cytoplasm. La présente invention concerne de nouveaux lipides ionisés et des nanoparticules lipidiques comprenant les lipides ionisés. Un agent thérapeutique utilisant les nanoparticules lipidiques comprenant des lipides ionisés d'un nouveau type selon la présente invention peut réduire au minimum les effets secondaires in vivo dus aux composants des nanoparticules, transférer de manière efficace les nanoparticules à des cellules cibles, et s'échapper aux endosomes dans des cellules cibles, ce qui permet de transférer efficacement une substance pharmaceutiquement efficace, telle qu'un acide nucléique, au cytoplasme. 본 발명은 신규 이온화 지질과 상기 이온화 지질을 포함하는 지질 나노입자에 관한 것으로, 본 발명에 따른 새로운 형태의 이온화 지질을 포함하는 지질 나노입자를 이용한 치료제는 나노입자의 구성 성분으로 인한 생체내 부작용을 최소화하고, 나노입자를 타겟 세포로 효과적으로 전달하며, 타겟 세포내의 엔도좀을 탈피하여 핵산 등의 약리 효능 물질을 세포질로 효율적으로 운반할 수 있다.