ACID-RESPONSIVE ANTICANCER PEPTIDE AND PREPARATION METHOD THEREFOR

An artificially synthesized anticancer peptide and an acid-responsive nanoparticle precursor thereof. The nanoparticle is formed by means of linking the anticancer peptide with an amphiphilic monomethyl polyethylene glycol-polypropylene glycol polymer by means of an acid-responsive chemical bond. It is proved by means of tests that the anticancer peptide kills tumor cells by means of a membrane-breaking activity, and has the advantages of excellent broad-spectrum anticancer activities and anti-drug resistance. The nanoparticle is selectively sensitive to the slightly acidic environments of tumors, can completely release the anticancer peptide, plays an active role in targeting tumor cell lines, and has the advantages of anti-hemolysis, high plasma stability, low systemic toxicity in vivo, capable of being administered systematically, etc. The nanoparticle has an obvious inhibitory effect on various tumor cells including triple negative breast cancer, and particularly has good clinical application potential fo