INHIBITORS OF NLRP3

The present invention relates to compounds that are useful as inhibitors of NOD-like receptor protein 3 (NLRP3) inflammasome pathway, processes for the preparation of said compounds, pharmaceutical compositions comprising said compounds, methods of using said compounds in the treatment of various di...

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Bibliographische Detailangaben
Hauptverfasser:	PARKER, Erica N, BEJCEK, Lauren, HOSSEYNI, Seyedmorteza, SYDORENKO, Nadiya, PILLAI, Meenu, HUARTE, Eduardo, ZHANG, Nanjing, GILBERT, Bradley B, Handoko, LI, Jing, WOLL, Matthew G, ALAM, Rauful, ZHANG, Xiaoyan, NIEDERER, Kyle, ZHENG, Tianyi, LIU, Yao, RASTELLI, Ettore
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to compounds that are useful as inhibitors of NOD-like receptor protein 3 (NLRP3) inflammasome pathway, processes for the preparation of said compounds, pharmaceutical compositions comprising said compounds, methods of using said compounds in the treatment of various diseases and disorders, and medicaments containing them, and their use in diseases and disorders mediated by NLRP3. La présente invention concerne des composés qui sont utiles en tant qu'inhibiteurs de la voie de l'inflammasome de la protéine 3 du récepteur de type NOD (NLRP3), des procédés pour la préparation desdits composés, des compositions pharmaceutiques comprenant lesdits composés, des méthodes d'utilisation desdits composés dans le traitement de divers maladies et troubles, et des médicaments les contenant, et leur utilisation dans des maladies et des troubles médiés par NLRP3.