STABLE FORMULATIONS COMPRISING THIOTEPA

The present disclosure provides pharmaceutical compositions comprising thiotepa, water, one selected from PEG, such as PEG400 or PEG600, and DMSO, and optionally thiosulfate or such compositions which is free or substantially free of impurities. Also provided is a method for treating cancer in a sub...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	RYAN, Orlaith, CUNNINGHAM, Sharon, PLATTEEUW, Johannes Jan
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present disclosure provides pharmaceutical compositions comprising thiotepa, water, one selected from PEG, such as PEG400 or PEG600, and DMSO, and optionally thiosulfate or such compositions which is free or substantially free of impurities. Also provided is a method for treating cancer in a subject, or myeloablation prior to bone marrow transplantation using the composition. A method for enhancing the stability of a thiotepa formulation is also contemplated. La présente invention concerne des compositions pharmaceutiques comprenant du thiotépa, de l'eau, un élément choisi parmi le PEG, tel que PEG400 ou PEG600, et le DMSO, et éventuellement du thiosulfate ou de telles compositions qui sont exemptes ou sensiblement exemptes d'impuretés. L'invention concerne également une méthode de traitement du cancer chez un sujet, ou une myéloablation avant une greffe de moelle osseuse à l'aide de la composition. L'invention concerne en outre un procédé d'amélioration de la stabilité d'une formulation de thiotépa.