SYNTHESIS OF BRUTON'S TYROSINE KINASE INHIBITORS

SYNTHESIS OF BRUTON'S TYROSINE KINASE INHIBITORS

The present disclosure is directed to methods of synthesizing a compound of Formula (I), where the R groups are defined herein, and to methods of synthesizing a compound of Formula (II). Some aspects of the present disclosure is directed to converting the compound of Formula (II) into its P form. La...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TRAN, Ngoc Duc, FERNANDES, Philippe, XIOURAS, Christos, CLEATOR, Edward, MATON, William Marc, RAMMELOO, Thomas Joachim Landewald
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present disclosure is directed to methods of synthesizing a compound of Formula (I), where the R groups are defined herein, and to methods of synthesizing a compound of Formula (II). Some aspects of the present disclosure is directed to converting the compound of Formula (II) into its P form. La présente divulgation concerne des méthodes de synthèse d'un composé de formule (I), les groupes R étant définis dans la description, et des méthodes de synthèse d'un composé de formule (II). Certains aspects de la présente divulgation concernent la conversion du composé de formule (II) en sa forme P.