METHOD FOR REALIZING CONTROLLED RELEASE AND SUSTAINED RELEASE OF ACTIVITY OF BIOACTIVE MOLECULES AND USE FOR DRUGS

Provided are a method for realizing the controlled release and sustained release of the activity of bioactive molecules and use for drugs. Provided is a PEG modifier of a specific structure. The PEG modifier can be widely applied to the controlled release and sustained release of the activity of various bioactive molecules. Provided is a conjugate formed by reacting the PEG modifier of the specific type and structure with IL-2. In a certain in vitro condition or in vivo physiological condition, PEG gradually falls off from the conjugate and the activity of IL-2 is gradually released, so that a certain effective plasma concentration where bioactive molecules are relatively stable can be maintained, and thus the in vivo or in vitro sustained release and controlled release of the activity of the drug are realized. L'invention concerne un procédé permettant de réaliser une libération contrôlée et une libération prolongée de l'activité de molécules bioactives et une utilisation pour des médicaments. L'invention co