METHODS AND COMPOSITIONS FOR TREATING CANCER IN TAXANE-RESISTANT PATIENTS

METHODS AND COMPOSITIONS FOR TREATING CANCER IN TAXANE-RESISTANT PATIENTS

Methods and compositions are provided for treating cancer in a taxane-resistant patient, comprising administering an effective dose of a taxane simultaneously or sequentially with a P-gp inhibitor, such as ritonavir or a pharmaceutically acceptable salt thereof. Also provided are methods and composi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VAN DER PUTTEN, Eric, FREUND, Colin
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Methods and compositions are provided for treating cancer in a taxane-resistant patient, comprising administering an effective dose of a taxane simultaneously or sequentially with a P-gp inhibitor, such as ritonavir or a pharmaceutically acceptable salt thereof. Also provided are methods and compositions for reversing taxane resistance in a patient, comprising administering an effective dose of a P-gp inhibitor, such as ritonavir or a pharmaceutically acceptable salt thereof. L'invention concerne des méthodes et des compositions pour le traitement du cancer chez un patient résistant au taxane, comprenant l'administration d'une dose efficace d'un taxane simultanément ou séquentiellement avec un inhibiteur de P-gp, tel que le ritonavir ou un sel pharmaceutiquement acceptable de celui-ci. L'invention concerne également des méthodes et des compositions pour inverser la résistance au taxane chez un patient, comprenant l'administration d'une dose efficace d'un inhibiteur de P-gp, tel que le ritonavir ou un sel pharmaceutiquement acceptable de celui-ci.