METHODS FOR ACTIVATION AND EXPANSION OF T CELLS

Methods for culturing and expanding lymphocytes using unconventional cytokines are provided. These methods include techniques for culturing and expanding lymphocytes using streamlined approaches, including approaches using agonists for stimulation, and approaches more suitable for clinical manufactu...

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Hauptverfasser: DENIGER, Drew Caldwell, CARPIO, Victor, COLLINSON-PAUTZ, Matthew, JOO, Donghyun, SHI, Yaoyao, HURTON, Lenka Victoria, LU, An
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Methods for culturing and expanding lymphocytes using unconventional cytokines are provided. These methods include techniques for culturing and expanding lymphocytes using streamlined approaches, including approaches using agonists for stimulation, and approaches more suitable for clinical manufacturing. Compositions of expanded populations of lymphocytes are also provided. L'invention concerne des méthodes de culture et d'expansion de lymphocytes à l'aide de cytokines non conventionnelles. Lesdites méthodes comprennent des techniques de culture et d'expansion de lymphocytes à l'aide d'approches rationalisées, notamment des approches utilisant des agonistes pour la stimulation, et des approches plus appropriées pour la fabrication clinique. L'invention concerne également des compositions de populations étendues de lymphocytes.