PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS
Disclosed are methods of making selective estrogen receptor degraders (SERDs) of Formula (A), as well as intermediates thereof, salts thereof including a pharmaceutically acceptable salt, and pharmaceutical compositions thereof: wherein either R1 or R2 is independently Cl, F, -CF3, or -CH3, and the...
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| creator | HAWK, Mai Khanh Nguyen KJELL, Douglas Patton ARGUELLES DELGADO, Alonso Jose LU, Yu CZESKIS, Boris Arnoldovich REMICK, David Michael MAGNUS, Nicholas Andrew |
| description | Disclosed are methods of making selective estrogen receptor degraders (SERDs) of Formula (A), as well as intermediates thereof, salts thereof including a pharmaceutically acceptable salt, and pharmaceutical compositions thereof: wherein either R1 or R2 is independently Cl, F, -CF3, or -CH3, and the other is H; and R7 is H or PG.
L'invention concerne des méthodes de fabrication d'agents de dégradation sélectifs du récepteur des œstrogènes (SERD) de formule (A), ainsi que des intermédiaires de ceux-ci, des sels de ceux-ci comprenant un sel pharmaceutiquement acceptable, et des compositions pharmaceutiques de ceux-ci : (A) dans laquelle soit R1 soit R2 correspondant indépendamment à Cl, à F, à -CF3, ou à -CH3, et l'autre à H; et R7 correspondant à H ou à PG. |
| format | Patent |
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L'invention concerne des méthodes de fabrication d'agents de dégradation sélectifs du récepteur des œstrogènes (SERD) de formule (A), ainsi que des intermédiaires de ceux-ci, des sels de ceux-ci comprenant un sel pharmaceutiquement acceptable, et des compositions pharmaceutiques de ceux-ci : (A) dans laquelle soit R1 soit R2 correspondant indépendamment à Cl, à F, à -CF3, ou à -CH3, et l'autre à H; et R7 correspondant à H ou à PG.</description><language>eng ; fre</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230810&DB=EPODOC&CC=WO&NR=2023150056A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230810&DB=EPODOC&CC=WO&NR=2023150056A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HAWK, Mai Khanh Nguyen</creatorcontrib><creatorcontrib>KJELL, Douglas Patton</creatorcontrib><creatorcontrib>ARGUELLES DELGADO, Alonso Jose</creatorcontrib><creatorcontrib>LU, Yu</creatorcontrib><creatorcontrib>CZESKIS, Boris Arnoldovich</creatorcontrib><creatorcontrib>REMICK, David Michael</creatorcontrib><creatorcontrib>MAGNUS, Nicholas Andrew</creatorcontrib><title>PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS</title><description>Disclosed are methods of making selective estrogen receptor degraders (SERDs) of Formula (A), as well as intermediates thereof, salts thereof including a pharmaceutically acceptable salt, and pharmaceutical compositions thereof: wherein either R1 or R2 is independently Cl, F, -CF3, or -CH3, and the other is H; and R7 is H or PG.
L'invention concerne des méthodes de fabrication d'agents de dégradation sélectifs du récepteur des œstrogènes (SERD) de formule (A), ainsi que des intermédiaires de ceux-ci, des sels de ceux-ci comprenant un sel pharmaceutiquement acceptable, et des compositions pharmaceutiques de ceux-ci : (A) dans laquelle soit R1 soit R2 correspondant indépendamment à Cl, à F, à -CF3, ou à -CH3, et l'autre à H; et R7 correspondant à H ou à PG.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQBuAsDqK-w4GzkLbUPaR_2oL0wl2wYykSJ9FCfX908AGcvuXbmhCFPVShFFgodaAoiE5c6nkgDqS4wKf-CoIm4RYDCTxi-vYGrbgGonuzuc-PNR9-7swxIPnulJfXlNdlvuVnfk8jl7asitra-uyK6r_1AXvMLWY</recordid><startdate>20230810</startdate><enddate>20230810</enddate><creator>HAWK, Mai Khanh Nguyen</creator><creator>KJELL, Douglas Patton</creator><creator>ARGUELLES DELGADO, Alonso Jose</creator><creator>LU, Yu</creator><creator>CZESKIS, Boris Arnoldovich</creator><creator>REMICK, David Michael</creator><creator>MAGNUS, Nicholas Andrew</creator><scope>EVB</scope></search><sort><creationdate>20230810</creationdate><title>PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS</title><author>HAWK, Mai Khanh Nguyen ; KJELL, Douglas Patton ; ARGUELLES DELGADO, Alonso Jose ; LU, Yu ; CZESKIS, Boris Arnoldovich ; REMICK, David Michael ; MAGNUS, Nicholas Andrew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023150056A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>HAWK, Mai Khanh Nguyen</creatorcontrib><creatorcontrib>KJELL, Douglas Patton</creatorcontrib><creatorcontrib>ARGUELLES DELGADO, Alonso Jose</creatorcontrib><creatorcontrib>LU, Yu</creatorcontrib><creatorcontrib>CZESKIS, Boris Arnoldovich</creatorcontrib><creatorcontrib>REMICK, David Michael</creatorcontrib><creatorcontrib>MAGNUS, Nicholas Andrew</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HAWK, Mai Khanh Nguyen</au><au>KJELL, Douglas Patton</au><au>ARGUELLES DELGADO, Alonso Jose</au><au>LU, Yu</au><au>CZESKIS, Boris Arnoldovich</au><au>REMICK, David Michael</au><au>MAGNUS, Nicholas Andrew</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS</title><date>2023-08-10</date><risdate>2023</risdate><abstract>Disclosed are methods of making selective estrogen receptor degraders (SERDs) of Formula (A), as well as intermediates thereof, salts thereof including a pharmaceutically acceptable salt, and pharmaceutical compositions thereof: wherein either R1 or R2 is independently Cl, F, -CF3, or -CH3, and the other is H; and R7 is H or PG.
L'invention concerne des méthodes de fabrication d'agents de dégradation sélectifs du récepteur des œstrogènes (SERD) de formule (A), ainsi que des intermédiaires de ceux-ci, des sels de ceux-ci comprenant un sel pharmaceutiquement acceptable, et des compositions pharmaceutiques de ceux-ci : (A) dans laquelle soit R1 soit R2 correspondant indépendamment à Cl, à F, à -CF3, ou à -CH3, et l'autre à H; et R7 correspondant à H ou à PG.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS |
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