PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS

PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS

Disclosed are methods of making selective estrogen receptor degraders (SERDs) of Formula (A), as well as intermediates thereof, salts thereof including a pharmaceutically acceptable salt, and pharmaceutical compositions thereof: wherein either R1 or R2 is independently Cl, F, -CF3, or -CH3, and the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: HAWK, Mai Khanh Nguyen, KJELL, Douglas Patton, ARGUELLES DELGADO, Alonso Jose, LU, Yu, CZESKIS, Boris Arnoldovich, REMICK, David Michael, MAGNUS, Nicholas Andrew
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Disclosed are methods of making selective estrogen receptor degraders (SERDs) of Formula (A), as well as intermediates thereof, salts thereof including a pharmaceutically acceptable salt, and pharmaceutical compositions thereof: wherein either R1 or R2 is independently Cl, F, -CF3, or -CH3, and the other is H; and R7 is H or PG. L'invention concerne des méthodes de fabrication d'agents de dégradation sélectifs du récepteur des œstrogènes (SERD) de formule (A), ainsi que des intermédiaires de ceux-ci, des sels de ceux-ci comprenant un sel pharmaceutiquement acceptable, et des compositions pharmaceutiques de ceux-ci : (A) dans laquelle soit R1 soit R2 correspondant indépendamment à Cl, à F, à -CF3, ou à -CH3, et l'autre à H; et R7 correspondant à H ou à PG.