PHARMACEUTICAL COMPOSITIONS AND METHODS OF ADMINISTRATION

The present disclosure describes novel compounds and compositions and methods of making and using thereof related that are capable of inhibiting PAK1 and associated diseases or disorders, including tumors and cancerous cells. The inventive compounds are more efficacious and stable than IPA-3 without...

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Bibliographische Detailangaben
Hauptverfasser:	SHENOY, Somanath, GESELOWITZ, Daniel A, CUMMINGS, Brian, CRICH, David, HOMAN, Harvey D
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present disclosure describes novel compounds and compositions and methods of making and using thereof related that are capable of inhibiting PAK1 and associated diseases or disorders, including tumors and cancerous cells. The inventive compounds are more efficacious and stable than IPA-3 without needing liposomal formulations as vehicles for the compounds. La présente invention concerne des composés et compositions nouveaux et leurs procédés de fabrication et d'utilisation associés qui sont capables d'inhiber PAK1 et des maladies ou des troubles associés, y compris des tumeurs et des cellules cancéreuses. Les composés de l'invention sont plus efficaces et stables que l'IPA-3 sans nécessiter de formulations liposomales en tant que véhicules pour les composés.