YEAST ENGINEERING BACTERIUM FOR FERMENTATIVE PRODUCTION OF α-SANTALENE AND USE THEREOF

Disclosed are a yeast engineering bacterium for fermentative production of α-santalene and use thereof. Yeast is used as an original strain, and by means of the introduction of a gene construct, a yeast engineering bacterium that can efficiently produce α-santalene is obtained, with a fermentation yield of nearly 3.0 g/L in a shake flask and a fermentation yield of up to 15 g/L in a 1 L fermentor. By means of a high expression of a key rate-limiting enzyme in a metabolic pathway, an enhanced precursor supply, and a multi-copy strategy, metabolic fluxes in a biosynthetic pathway of α-sandalene are improved. Pichia pastoris is used in the efficient production of α-santalene, and the production is characterized by short period, environmental friendliness, and resource conservation. Bactérie issue du génie génétique des levures pour la production fermentaire d'α-santalène et son utilisation. La levure est utilisée comme souche originelle et l'introduction d'une construction génétique permet d'obtenir une bactérie