OXAZOLE DERIVATIVE COMPOUND HAVING ANTIBACTERIAL ACTIVITY AND MEDICAL USE THEREOF

The present disclosure provides a novel oxazole derivative compound having anti-Mycobacterium tuberculosis activity or a pharmaceutically acceptable salt thereof. The present disclosure also provides an antibacterial composition comprising the compound or a pharmaceutically acceptable salt thereof....

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Bibliographische Detailangaben
Hauptverfasser:	KIM, Young Mi, AHN, Ji Eun, SON, Eunsoon, JEONG, Mi Ji, KIM, Kyungjong, YANG, Jeong Seong, LEE, Ji-im, PARK, Yumi, LEE, Aram, LEE, Jong Seok, WHANG, Jake, CUI, Lianji, CHOI, Inhee
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure provides a novel oxazole derivative compound having anti-Mycobacterium tuberculosis activity or a pharmaceutically acceptable salt thereof. The present disclosure also provides an antibacterial composition comprising the compound or a pharmaceutically acceptable salt thereof. The novel oxazole compound according to the present disclosure has remarkably excellent antibacterial activity, particularly anti-Mycobacterium tuberculosis activity, and thus can be effectively used in the prevention or treatment of diseases caused by bacterial infection. La présente invention concerne un nouveau composé dérivé d'oxazole ayant une activité anti-Mycobacterium tuberculosis ou un sel pharmaceutiquement acceptable de celui-ci. La présente invention concerne également une composition antibactérienne comprenant le composé ou un sel pharmaceutiquement acceptable de celui-ci. Le nouveau composé oxazole selon la présente invention présente une activité antibactérienne remarquablement excellente, en particulier une activité anti-Mycobacterium tuberculosis, et peut ainsi être efficacement utilisé dans la prévention ou le traitement de maladies causées par une infection bactérienne. 본 개시는 항결핵균 활성을 가지는 신규 옥사졸 유도체 화합물 또는 이의 약학적으로 허용 가능한 염을 제공한다. 본 개시는 또한 이러한 화합물 또는 이의 약학적으로 허용 가능한 염을 포함하는 항박테리아용 조성물을 제공한다. 본 개시에 따른 신규 옥사졸 화합물은 항박테리아, 특히 항결핵 활성이 현저히 우수하여, 박테리아 감염에 의해 발병되는 질환의 예방 또는 치료에 유용하게 사용할 수 있다.