SALT FORM CRYSTAL FORM OF PYRIMIDINE DERIVATIVE AND PREPARATION METHOD THEREFOR

Provided in the present invention are a salt form crystal form of a pyrimidine derivative and a preparation method therefor, which belong to the field of chemistry. The crystal form of the pyrimidine derivative is an ethanolamine salt crystal form A, a tert-butylamine salt crystal form A, a tert-but...

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Hauptverfasser: GONG, Jiafu, WU, Chenglong, HUANG, Jinkun, WANG, Qiang, XIE, Dejian
Format: Patent
Sprache:chi ; eng ; fre
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Zusammenfassung:Provided in the present invention are a salt form crystal form of a pyrimidine derivative and a preparation method therefor, which belong to the field of chemistry. The crystal form of the pyrimidine derivative is an ethanolamine salt crystal form A, a tert-butylamine salt crystal form A, a tert-butylamine salt crystal form B, a meglumine salt crystal form A, a potassium salt crystal form A, a magnesium salt crystal form A, a magnesium salt crystal form B, a calcium salt crystal form A, a hydrobromate crystal form A, a hydrobromate crystal form B, a hydrobromate crystal form C, a hydrobromate crystal form D or an L-arginine salt crystal form A of a pyrimidine derivative a srepresented by formula (I). The salt form crystal form of the pyrimidine derivative has good stability, good solubility, high bioavailability, a good drug effect and good safety. Compared with a pyrimidine derivative as represented by formula (I), the pyrimidine derivative of the present invention has the advantages of significantly improvi