STABLE SOLUTION, PREPARATION METHOD, USE, PHARMACEUTICAL COMPOSITION AND KIT
A stable solution, a pharmaceutical composition with a storage or administration method as a stable solution, a pharmaceutical product of the stable solution, a preparation method therefor and the use thereof, and a kit. The stable solution contains a drug and water, and the drug comprises arginine....
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Zusammenfassung: | A stable solution, a pharmaceutical composition with a storage or administration method as a stable solution, a pharmaceutical product of the stable solution, a preparation method therefor and the use thereof, and a kit. The stable solution contains a drug and water, and the drug comprises arginine. The arginine in the stable solution is in a dissolved state at a temperature T, the percentage ratio of the arginine to water is C1, and the arginine has a water solubility of C2 at the temperature T, wherein T is the storage or administration ambient temperature of the stable solution, such as 0-37℃, and C1>C2. The stable solution still maintains a supersaturated concentration ratio of C1/C2>1.0 within the required stable time under the unstable conditions of a conventional supersaturated solution. The stable solution can be stably present at a relatively low temperature T, especially in a working environment E favorable for crystallization, and has an ultra-high concentration, which provides more new options for |
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