ANTIGEN DELIVERY PLATFORM AND METHODS OF USE

Provided herein are compositions and methods for inducing an immune response in a subject, wherein the compositions comprise apoptotic cells, extracellular vesicles (EVs), and combinations thereof. Various compositions comprising mRNA encoding a microbial antigen are also provided. Further provided...

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Bibliographische Detailangaben
Hauptverfasser:	CHOUDHRY, Modassir, HENLEY, Thomas
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are compositions and methods for inducing an immune response in a subject, wherein the compositions comprise apoptotic cells, extracellular vesicles (EVs), and combinations thereof. Various compositions comprising mRNA encoding a microbial antigen are also provided. Further provided herein are compositions engineered to overexpress the human arrestin domain containing protein 1 [ARRDC1]. L'invention concerne des compositions et des procédés pour induire une réponse immunitaire chez un sujet, les compositions comprenant des cellules apoptotiques, des vésicules extracellulaires (VE), ainsi que des combinaisons de ceux-ci. L'invention concerne également diverses compositions comprenant de l'ARNm codant pour un antigène microbien. L'invention concerne en outre des compositions modifiées pour surexprimer la protéine 1 contenant le domaine arrestine humaine [ARRDC1].