SPLICE SWITCH OLIGONUCLEOTIDE (SSO) MOLECULES FOR TARGETING β-CATENIN AND USES THEREOF

The present disclosure relates to the field of pharmaceutical compounds and preparations and method of their use in the treatment of disease. Described are splice switch oligonucleotide (SSO) molecules for targeting β-catenin, compositions containing the same, and uses thereof for treating or preven...

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Bibliographische Detailangaben
Hauptverfasser:	BEIGELMAN, Leonid, BHATTACHARYA, Aneerban, HUANG, Vera, HONG, Jin, ELTEPU, Laxman
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure relates to the field of pharmaceutical compounds and preparations and method of their use in the treatment of disease. Described are splice switch oligonucleotide (SSO) molecules for targeting β-catenin, compositions containing the same, and uses thereof for treating or preventing β-catenin associated diseases or disorders. In particular, the present invention is in the field of SSO molecules that targets β-catenin for treatment of cancer. La présente invention se rapporte au domaine de composés et de préparations pharmaceutiques et à leur méthode d'utilisation dans le traitement d'une maladie. L'invention concerne des molécules d'oligonucléotide modulant l'épissage (SSO) pour cibler la bêta-caténine, des compositions les contenant, et leurs utilisations pour traiter ou prévenir des maladies ou des troubles associés à la bêta-caténine. En particulier, la présente invention concerne le domaine des molécules SSO qui ciblent la bêta-caténine pour le traitement du cancer.