DRUG DELIVERY SYSTEM AND METHODS OF USING THE SAME

A method of preparing an implantable biomaterial includes combining a polymer comprising polydioxanone with a neuro-regenerative agent or an immunosuppressive agent comprising at least one immunophilin ligand, and melting the polymer. The method further includes extruding the combined polymer and th...

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Bibliographische Detailangaben
Hauptverfasser:	SCOPELIANOS, Angelo, TAJDARAN, Kasra, DEUERLING, Justin, DILUCCIO, Robert
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A method of preparing an implantable biomaterial includes combining a polymer comprising polydioxanone with a neuro-regenerative agent or an immunosuppressive agent comprising at least one immunophilin ligand, and melting the polymer. The method further includes extruding the combined polymer and the neuro-regenerative agent or immunosuppressive agent to form the implantable biomaterial. Un procédé de préparation d'un biomatériau implantable comprend la combinaison d'un polymère comprenant de la polydioxanone avec un agent neuro-régénérateur ou un agent immunosuppresseur comprenant au moins un ligand d'immunophiline, ainsi que la fusion du polymère. Le procédé comprend en outre l'extrusion du polymère combiné et de l'agent neuro-régénérateur ou de l'agent immunosuppresseur pour former le biomatériau implantable.