A PREPARATION OF QUINAZOLINEDIONES AND USE THEREOF

The present invention described herein relates to a compound having Structure I for treating diseases and disorders for which inhibition or modulation of the Ubiquitin Ligase COP1 enzyme produces a physiologically beneficial response, in particular for the treatment of Non-Alcoholic Fatty Liver Dise...

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Bibliographische Detailangaben
Hauptverfasser:	HOQUE, Israful, TALUKDAR, Arindam, GHOSH DASTIDAR, Uddipta, SARKAR, Dipayan, GOON, Sunny, SEN, Abhishek, CHOWDHURY, Saheli, PATRA, Binita, CHAKRABARTI, Partha
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention described herein relates to a compound having Structure I for treating diseases and disorders for which inhibition or modulation of the Ubiquitin Ligase COP1 enzyme produces a physiologically beneficial response, in particular for the treatment of Non-Alcoholic Fatty Liver Disease (NAFLD). These compounds having Structure I are capable of increasing the level of adipose triglyceride lipase (ATGL). Also provided is the process of preparing compounds having Structure I. La présente invention concerne un composé ayant une structure I pour le traitement de maladies et de troubles pour lesquels l'inhibition ou la modulation de l'enzyme ubiquitine ligase COP1 produit une réponse physiologiquement bénéfique, en particulier pour le traitement de la stéatose hépatique non alcoolique (NAFLD). Ces composés ayant la structure I sont capables d'augmenter le taux de lipase des triglycérides des tissus adipeux (ATGL). L'invention concerne également le procédé de préparation de composés ayant la structure I.