DEUBIQUITINASE INHIBITORS AND METHODS OF USE THEREOF

The inventive compounds of formula (I) are small molecule therapeutics that are potent inhibitors of USP7 activity. The invention also provides pharmaceutical compositions comprising the compounds (I), and methods for using the compounds for treating or preventing a disease, disorder, or condition a...

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Hauptverfasser:	MUCHOWICZ, Angelika, CHRZANOWSKI, Jacek, JOACHIMIAK, Lukasz, OLCZAK, Jacek, MAZUR, Marzena, ZASLONA, Zbigniew, GZIK, Anna, CIASTEK-ISKRZYCKA, Sylwia, MATYSZEWSKI, Krzysztof, NIEDZIEJKO, Piotr, GOLEBIOWSKI, Adam, OLEJNICZAK, Sylwia, NOWICKA, Julita, KORALEWSKI, Robert, BOREK, Bartlomiej, BLASZCZYK, Roman
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The inventive compounds of formula (I) are small molecule therapeutics that are potent inhibitors of USP7 activity. The invention also provides pharmaceutical compositions comprising the compounds (I), and methods for using the compounds for treating or preventing a disease, disorder, or condition associated with USP7 activity. Les composés de formule (I) selon l'invention sont des agents thérapeutiques à petites molécules qui sont des inhibiteurs puissants de l'activité de l'USP7. L'invention concerne également des compositions pharmaceutiques comprenant les composés (I), et des procédés d'utilisation des composés pour traiter ou prévenir une maladie, un trouble ou un état associé à l'activité de USP7.