ANTIBODY AGAINST HUMAN TIGIT AND USE THEREOF

The present invention belongs to the technical field of antibodies, and discloses an antibody against human TIGIT and the use thereof. The antibody against human TIGIT or an antigen-binding fragment thereof has a strong binding ability to hTIGIT, can induce B-hTIGIT transgenic mouse T cells, Jurkat...

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Bibliographische Detailangaben
Hauptverfasser:	YE, Yuqing, WANG, Xiaofei, ZENG, Min, YE, Caiguo, LU, Huijuan
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention belongs to the technical field of antibodies, and discloses an antibody against human TIGIT and the use thereof. The antibody against human TIGIT or an antigen-binding fragment thereof has a strong binding ability to hTIGIT, can induce B-hTIGIT transgenic mouse T cells, Jurkat cells and human PBMC cells to secrete cytokines, has a significant ADCC effect and CDC effect, can significantly reduce the tumor volume/weight in tumor bearing mice implanted with a colon cancer cell line CT26 and tumor bearing mice implanted with a breast cancer cell line 4T1 without affecting the body weight of the mice, that is, without side effects, and prolong the survival time of the mice, and also has good pharmacokinetic properties, and can be used for detecting the expression level of hTIGIT and treating tumors. La présente invention relève du domaine technique des anticorps, et concerne un anticorps dirigé contre TIGIT humain et son utilisation. L'anticorps dirigé contre TIGIT humain ou un fragment de li