METHOD OF DEVELOPING A PEPTIDE-BASED VACCINE CONJUGATED WITH 1V209

Provided are a composition comprising a peptide conjugated to a TLR agonist, including TLR7 agonist 1v209, and methods of using the composition. The methods comprise administering the peptide-based vaccine conjugate to a subject. The peptide-based vaccine conjugate inhibits tumor growth and induces...

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Bibliographische Detailangaben
Hauptverfasser:	HU, Yefan, HUANG, Jiandong
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are a composition comprising a peptide conjugated to a TLR agonist, including TLR7 agonist 1v209, and methods of using the composition. The methods comprise administering the peptide-based vaccine conjugate to a subject. The peptide-based vaccine conjugate inhibits tumor growth and induces antigen-specific B and T cell responses in a subject. L'invention concerne une composition comprenant un peptide conjugué à un agoniste TLR, comprenant l'agoniste TLR7 1v209, et des procédés d'utilisation de la composition. Les procédés comprennent l'administration du conjugué de vaccin à base de peptide à un sujet. Le conjugué de vaccin à base de peptide inhibe la croissance tumorale et induit des réponses de lymphocytes B et T spécifiques d'un antigène chez un sujet.