S1PR4 RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF

Described herein are compounds useful as S1PR4 receptor antagonists, pharmaceutical compositions comprising said compounds, methods of making said compounds and pharmaceutical compositions, and methods of using said compounds and pharmaceutical compositions in the treatment of disorders including ne...

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Bibliographische Detailangaben
Hauptverfasser:	GANCIA, Emanuela, BULL, Richard, JACKSON, Philip, KNIGHT, Jamie, LEVENSON, Jonathan Max, LARSON, Kelley Cronin, TATE, Barbara, JENNINGS, Neil, HYND, George, CRIDLAND, Andrew, MILLER, Thomas Allen, MARTENS, Lauren, BRUHN, Suzanne
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Described herein are compounds useful as S1PR4 receptor antagonists, pharmaceutical compositions comprising said compounds, methods of making said compounds and pharmaceutical compositions, and methods of using said compounds and pharmaceutical compositions in the treatment of disorders including neurological disorders, cognitive disorders, and neurodegenerative disorders. L'invention concerne des composés utiles en tant qu'antagonistes du récepteur S1PR4, des compositions pharmaceutiques comprenant lesdits composés, des procédés de fabrication desdits composés et des compositions pharmaceutiques, ainsi que des procédés d'utilisation desdits composés et compositions pharmaceutiques dans le traitement de troubles comprenant des troubles neurologiques, des troubles cognitifs et des troubles neurodégénératifs.