FUSION PROTEIN DISPLAYING SARS-COV-2 S PROTEIN, RECOMBINANT VIRION, AND USE OF FUSION PROTEIN AND RECOMBINANT VIRION

Provided in the present invention are a fusion protein displaying a SARS-COV-2 S protein, a recombinant virion, and the use of the fusion protein and the recombinant virion, which belong to the technical field of biological products. Provided in the present invention are a fusion gene expressing a SARS-COV-2 S protein, and a fusion protein, wherein the fusion gene or fusion protein contains the sequence of an extracellular domain of a SARS-COV-2 S protein and the sequences of a transmembrane domain and an intracellular domain of an Avian paramyxovirus (APMV) F protein. Meanwhile, a recombinant NDV virus containing the sequences has a strong ability to neutralize an antibody. It can be seen that the fusion gene or protein formed by means of fusing a sequence encoding an extracellular domain of an S protein with sequences encoding a transmembrane domain and an intracellular domain of an APMV (excluding NDV) F protein has great potential to be an excellent candidate antigen for a SARS-COV-2 vaccine. La présente