HETEROCYCLIC COMPOUND WITH AKT KINASE INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF

Provided are a heterocyclic compound with AKT kinase inhibitory activity, a preparation method therefor and a medical use thereof. In particular, the invention relates to a compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing same, and a...

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Bibliographische Detailangaben
Hauptverfasser:	DU, Peijin, CHEN, Zhenhua, SHANG, Fei, YAN, Xu, CAI, Xucan, LIU, Guobiao
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are a heterocyclic compound with AKT kinase inhibitory activity, a preparation method therefor and a medical use thereof. In particular, the invention relates to a compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing same, and a use thereof as an AKT kinase inhibitor in a drug for the prevention and/or treatment of abnormal cell growth such as cancer. The definitions of groups in general formula (I) are the same as that in the description. L'invention concerne un composé hétérocyclique ayant une activité inhibitrice de kinase AKT, son procédé de préparation et son utilisation médicale. En particulier, l'invention concerne un composé représenté par la formule générale (I), son procédé de préparation, une composition pharmaceutique le contenant, et son utilisation en tant qu'inhibiteur de kinase AKT dans un médicament pour la prévention et/ou le traitement d'une croissance cellulaire anormale telle que le cancer. Les définitions des groupes