PYRIDOXAL-5-PHOSPHATE (P5P) ANALOGS

Disclosed are compound, its stereoisomer, salt, hydrate, solvate, isotope or crystalline form thereof, represented by Formula (I), with X, R1, R2, R3, R4 and R5 as disclosed herein. Also, disclosed is a process for their preparation, compositions containing such compounds, methods of medical treatme...

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Bibliographische Detailangaben
Hauptverfasser:	TWIBANIRE, Jean-d'amour K, KAUR, Matinder, CHEHAL, Navneet, PIPALIYA, Bhavin, VAKITI, Ramkrishna Reddy, CARLIN, Kevin P, HUSSAINI, Syed Mohammed A, COOK, Cyril, TAJ, Rafiq A, FRIESEN, Albert D, KHAN, Qasim, ULLAH, Farman
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compound, its stereoisomer, salt, hydrate, solvate, isotope or crystalline form thereof, represented by Formula (I), with X, R1, R2, R3, R4 and R5 as disclosed herein. Also, disclosed is a process for their preparation, compositions containing such compounds, methods of medical treatment or prophylaxis of a disease by such compounds and uses thereof. The compounds of Formula (I) are pyridoxal-5-phosphate (P5P) analogs, and can act as prodrugs. Sont divulgués un composé, son stéréoisomère, son sel, son hydrate, son solvate, son isotope ou une forme cristalline de celui-ci, représenté par la formule (I), X, R1, R2, R3, R4 et R5 étant tels que décrits dans la description. Sont divulgués également un procédé pour leur préparation, des compositions contenant de tels composés, des méthodes de traitement médical ou de prophylaxie d'une maladie par de tels composés et leurs utilisations. Les composés de formule (I) sont des analogues de pyridoxal-5-phosphate (P5P), et peuvent agir en tant que promédicaments.