ENGINEERED GUIDE RNAS AND POLYNUCLEOTIDES FOR RNA EDITING TARGETING LRRK2

Disclosed herein are engineered latent guide RNAs targeting LRRK2 and compositions comprising the same for treatment of diseases or conditions (e.g. Parkinson's Disease) in a subject. Also disclosed herein are methods of treating diseases or conditions (e.g. Parkinson's Disease) in a subje...

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Bibliographische Detailangaben
Hauptverfasser:	SULLIVAN, Richard, DEAN, James Thaddeus, SAVVA, Yiannis, BOOTH, Brian, BRIGGS, Adrian, GUO, Lan, BAGEPALLI, Lina Rajill
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed herein are engineered latent guide RNAs targeting LRRK2 and compositions comprising the same for treatment of diseases or conditions (e.g. Parkinson's Disease) in a subject. Also disclosed herein are methods of treating diseases or conditions (e.g. Parkinson's Disease) in a subject by administering engineered latent guide RNAs or pharmaceutical compositions described herein. L'invention divulgue des ARN guides latents modifiés ciblant LRRK2 et des compositions les comprenant pour le traitement de maladies ou d'états (par exemple, la maladie de Parkinson) chez un sujet. L'invention divulgue également des procédés de traitement de maladies ou d'états (par exemple, la maladie de Parkinson) chez un sujet par l'administration d'ARN guides latents modifiés ou de compositions pharmaceutiques décrites ici.