KRAS DEGRADING COMPOUNDS COMPRISING ANNULATED 2-AMINO-3-CYANO THIOPHENES

The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases. La présente invention concerne des composés et des dérivés de formule (I) qui ciblent KRAS et peuvent être utiles en tant q...

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Hauptverfasser:	FARNABY, William, MANTOULIDIS, Andreas, SARKAR, Dhruba, TRAINOR, Nicole, LITTLE, Andrew, BROEKER, Joachim, KOFINK, Christiane, WEINSTABL, Harald, SMETHURST, Christian Alan Paul, SCHMIEDEL, Martin, CUI, Jianwen, DIERS, Emelyne, ZHONG, Siying, WATERSON, Alex, MCLENNAN, Ross, CIULLI, Alessio, ZOLLMAN, David, FESIK, Stephen W, GOODWIN-TINDALL, Jake, ABBOTT, Jason, GOLLNER, Andreas, POPOW, Johannes
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases. La présente invention concerne des composés et des dérivés de formule (I) qui ciblent KRAS et peuvent être utiles en tant qu'agents pour le traitement et/ou la prévention de maladies oncologiques.