CYTOSOLIC BACTERIAL PATHOGENS ATTENUATED FOR SPREAD FROM TUMORS AND METHODS OF USE THEREOF

In various embodiments Listeria, Burkholderia, and Rickettsia bacteria that are genetically mutated for their ability to spread, causing limited toxicity after delivery to tumors are provided. In certain embodiments the bacteria include the presence of an ablative mutation for cell-to-cell spread. S...

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Bibliographische Detailangaben
Hauptverfasser:	PORTNOY, Daniel A, WELCH, Matthew D, CHAVEZ-ARROYO, Alfredo, NICOLAI, Christopher J, BURKE II, Thomas Patrick
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	In various embodiments Listeria, Burkholderia, and Rickettsia bacteria that are genetically mutated for their ability to spread, causing limited toxicity after delivery to tumors are provided. In certain embodiments the bacteria include the presence of an ablative mutation for cell-to-cell spread. Some of the bacteria contain genetic mutations that enhance the ability to invade tumor cells. Pharmaceutical compositions comprising the bacteria, and administration routes useful in treatment of cancers are also provided. Dans divers modes de réalisation, la présente invention concerne des bactéries de Listeria, Burkholderia et Rickettsia génétiquement mutées pour leur capacité à se propager, provoquant une toxicité limitée après administration dans des tumeurs. Dans certains modes de réalisation, les bactéries comprennent la présence d'une mutation ablative pour un étalement de cellule à cellule. Certaines des bactéries contiennent des mutations génétiques qui améliorent la capacité d'invasion des cellules tumorales. L'invention concerne également des compositions pharmaceutiques comprenant les bactéries, et des voies d'administration utiles dans le traitement de cancers.