MODIFIED PEPTIDE-OLIGONUCLEOTIDE CONJUGATE

The present invention relates to a modified peptide-oligonucleotide conjugates (POC) composed of a cell-penetrating peptide (CPP) conjugated to an antisense oligonucleotide. The POC is able to regulate gene expression in the target cells and can thus be used in treatment of different disease such as...

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Bibliographische Detailangaben
Hauptverfasser:	PEREIRA, Sara Raquel do Souto, AZEVEDO, Nuno Filipe, WENGEL, Jesper Thagaard, SANTOS, Rita Sobral Fernandes Machado dos, MOREIRA, Luis Miguel de Aquino, GUIMARÃES, Nuno Miguel da Rocha
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a modified peptide-oligonucleotide conjugates (POC) composed of a cell-penetrating peptide (CPP) conjugated to an antisense oligonucleotide. The POC is able to regulate gene expression in the target cells and can thus be used in treatment of different disease such as bacterial infections and cancer. La présente invention concerne un conjugué peptide-oligonucléotide (POC) modifié composé d'un peptide de pénétration cellulaire (CPP) conjugué à un oligonucléotide antisens. Le POC peut réguler l'expression génique dans les cellules cibles et peut ainsi être utilisé dans le traitement de différentes maladies telles que les infections bactériennes et le cancer.