PAD4 INHIBITORS AND USE THEREOF

PAD4 INHIBITORS AND USE THEREOF

The present disclosure provides a compound represented by structural formula (I0) or a pharmaceutically acceptable salt, or a stereoisomer thereof and their use in, e.g. treating a disease or disorder associated with the PAD4 activity. This disclosure also features compositions containing the same a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: REN, Baoqi, WANG, Wei, GUO, Wei, REN, Xiaoming, YU, Bo, ZHONG, Wenge, WU, Lei, LI, Lige, MENG, Qingting, FENG, Song, YANG, Min
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure provides a compound represented by structural formula (I0) or a pharmaceutically acceptable salt, or a stereoisomer thereof and their use in, e.g. treating a disease or disorder associated with the PAD4 activity. This disclosure also features compositions containing the same as well as methods of using and making the same. La présente invention concerne un composé représenté par la formule structurale (I0) : ou un sel pharmaceutiquement acceptable, ou un stéréoisomère de celui-ci, et leur utilisation dans, par exemple, le traitement d'une maladie ou d'un trouble associé à l'activité de PAD4. La divulgation concerne également des compositions les contenant, ainsi que des procédés d'utilisation et de fabrication de celles-ci.