POLYMORPHS OF THE MESYLATE SALT OF LINAPRAZAN GLURATE

The present invention relates to polymorphs of the mesylate salt of 5-{2-[({8-[(2,6- dimethylbenzyl)amino]-2,3-dimethylimidazo[l,2-a]pyridine-6-yl}carbonyl)-amino]ethoxy}-5- oxopentanoic acid (linaprazan glurate), more specifically Form A and Form B of the mesylate salt of linaprazan glurate. The in...

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Bibliographische Detailangaben
Hauptverfasser:	LARSSON, Thomas, JARRING, Kjell
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to polymorphs of the mesylate salt of 5-{2-[({8-[(2,6- dimethylbenzyl)amino]-2,3-dimethylimidazo[l,2-a]pyridine-6-yl}carbonyl)-amino]ethoxy}-5- oxopentanoic acid (linaprazan glurate), more specifically Form A and Form B of the mesylate salt of linaprazan glurate. The invention also relates to pharmaceutical compositions comprising such polymorphs, and to the use of these polymorphs in the treatment or prevention of gastrointestinal inflammatory diseases or gastric acid related diseases, in particular erosive gastroesophageal reflux disease (eGERD). La présente invention concerne des polymorphes de sel mésylate de l'acide 5-{2-[({8-[(2,6- diméthylbenzyl)amino]-2,3-diméthylimidazo[l,2-a]pyridine-6-yl}carbonyl)-amino]éthoxy}-5-oxopentanoïque (linaprazan glurate), plus particulièrement la forme A et la forme B du sel mésylate de linaprazan glurate. L'invention concerne également des compositions pharmaceutiques comprenant de tels polymorphes, et l'utilisation de ces polymorphes dans le traitement ou la prévention de maladies inflammatoires gastro-intestinales ou de maladies associées à l'acide gastrique, en particulier le reflux gastro-œsophagien pathologique érosif (eGERD).