ENGINEERED CELL LINES FOR INCREASED PRODUCTION OF RECOMBINANT ADENO-ASSOCIATED VIRUS (RAAV)

This application relates to recombinant adeno-associated virus (rAAV) packaging and/or producer cell lines which have been engineered to reduce expression and/or activity of one or more genes and/or proteins to increase rAAV titers. The methods of generating the engineered cell lines have also been...

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Hauptverfasser:	TEDESCHI, Justin, RICHARDS, Nicholas, ADAMS, Caroline, PUGH, Charles, FULLER, Matthew Scott
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	This application relates to recombinant adeno-associated virus (rAAV) packaging and/or producer cell lines which have been engineered to reduce expression and/or activity of one or more genes and/or proteins to increase rAAV titers. The methods of generating the engineered cell lines have also been described herein. L'invention concerne des lignées cellulaires d'encapsidation et/ou de production de virus adéno-associés recombinés (rAAV) qui ont été modifiées pour réduire l'expression et/ou l'activité d'un ou de plusieurs gènes et/ou protéines pour augmenter les titres de rAAV. L'invention concerne également des procédés de génération desdites lignées cellulaires modifiées.