RXFP1 MODULATORS FOR THE TREATMENT OF HEART FAILURE

The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney d...

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Bibliographische Detailangaben
Hauptverfasser:	SU, Shun, PINTO, Donald J.P, SHAW, Scott A, PABBISETTY, Kumar Balashanmuga, MYERS, Michael C, MATHUR, Arvind, LI, Jianqing
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e.g., chronic kidney disease), or hepatic disease (e.g., non-alcoholic steatohepatitis and portal hypertension). L'invention concerne des composés de Formule (I), qui sont des agonistes du récepteur RXFP1, des compositions les contenant, et des procédés d'utilisation de ceux-ci, par exemple, dans le traitement d'une insuffisance cardiaque, de maladies fibrotiques et de maladies associées telles que la maladie pulmonaire (par exemple, la fibrose pulmonaire idiopathique), une maladie rénale (par exemple, une maladie rénale chronique), ou une maladie hépatique (par exemple, une stéatohépatite non alcoolique et une hypertension portale).