ALDEHYDE DEHYDROGENASE VARIANTS AND METHODS OF USE

The disclosure provides polypeptides and encoding nucleic acids of engineered aldehyde dehydrogenases. The disclosure also provides cells expressing an engineered form of the aldehyde dehydrogenase. The disclosure further provides methods for producing a bioderived compound, such as 3-hydroxybutyral...

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Bibliographische Detailangaben
Hauptverfasser:	WARNER, Joseph Roy, PRAVESCHOTINUNT, Pichet, SCHMIDT, Nathan, COLQUITT, Justin Robert, SHAH, Amit Mahendra
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The disclosure provides polypeptides and encoding nucleic acids of engineered aldehyde dehydrogenases. The disclosure also provides cells expressing an engineered form of the aldehyde dehydrogenase. The disclosure further provides methods for producing a bioderived compound, such as 3-hydroxybutyraldehyde, 1,3-butanediol, 4-hydroxybutyraldehyde, 1,4-butanediol, comprising culturing cells expressing an engineered aldehyde dehydrogenase. La présente divulgation concerne des polypeptides et des acides nucléiques codant des aldéhydes déshydrogénases modifiées. La divulgation concerne également des cellules exprimant une forme modifiée de l'aldéhyde déshydrogénase. La divulgation concerne en outre des méthodes de production d'un composé biodérivé, tel que le 3-hydroxybutyraldéhyde, le 1,3-butanediol, le 4-hydroxybutyraldéhyde, le 1,4-butanediol, comprenant la culture de cellules exprimant une aldéhyde déshydrogénase modifiée.