PEPTIDE CONJUGATES AND THERAPEUTIC AGENTS HAVING IMPROVED PHARMACOLOGICAL AND PHARMACOKINETIC PROPERTIES

Disclosed are conjugates, comprising a peptide moiety, a linker, and an active moiety. Also disclosed are methods of using the conjugates for treating a disease, inducing antigen-specific immunotolerance to the active moiety, or extending the half-life of the active moiety. L'invention concerne...

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Bibliographische Detailangaben
Hauptverfasser:	SAWYER, Jonathon R, PENTELUTE, Bradley L, SANTIAGO, Solimar G, SAWYER, Tomi K, GUNASEKERA, Dinara S
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are conjugates, comprising a peptide moiety, a linker, and an active moiety. Also disclosed are methods of using the conjugates for treating a disease, inducing antigen-specific immunotolerance to the active moiety, or extending the half-life of the active moiety. L'invention concerne des conjugués, comprenant une fraction peptidique, un lieur et une fraction active. L'invention concerne également des procédés d'utilisation des conjugués pour traiter une maladie, induire une immunotolérance spécifique de l'antigène au niveau de la fraction active, ou prolonger la demi-vie de la fraction active.