IN VITRO POTENCY ASSAY FOR PROTEIN-BASED MENINGOCOCCAL VACCINES USING A PLURALITY OF MONOCLONAL ANTIBODIES AND ANTIGENS IMMOBILIZED TO COLOUR-CODED BEADS

This invention provides a multiplex binding assay for analysing a meningococcal vaccine and assessing in vitro relative potency of the same (IVRP). The invention also provides monoclonal antibodies which bind to meningococcal proteins within the vaccine, and in particular monoclonal antibodies which...

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Bibliographische Detailangaben
Hauptverfasser:	MALZONE, Carmine, DEWAR, Vincent, FRIGIMELICA, Elisabetta, BACCONI, Marta, VEGGI, Daniele, PANSEGRAU, Werner, BARDELLI, Monia, BRUNELLI, Brunella
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
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Beschreibung
Zusammenfassung:	This invention provides a multiplex binding assay for analysing a meningococcal vaccine and assessing in vitro relative potency of the same (IVRP). The invention also provides monoclonal antibodies which bind to meningococcal proteins within the vaccine, and in particular monoclonal antibodies which are bactericidal for meningococcus and/or which recognise conformational epitopes within the meningococcal proteins. La présente invention concerne un immunoessai multiplex pour analyser un vaccin antiméningococcique et évaluer la puissance relative in vitro de celui-ci (IVRP). L'invention concerne également des anticorps monoclonaux qui se lient aux protéines méningococciques à l'intérieur du vaccin, et en particulier des anticorps monoclonaux qui sont bactéricides pour un méningocoque et/ou qui reconnaissent des épitopes conformationnels dans les protéines méningococciques.