POLYNUCLEOTIDES ENCODING INTERLEUKIN-12 (IL-12) AND RELATED COMPOSITION AND METHODS THEREOF

Provided herein are nucleic acid molecules encoding interleukin-12 (IL-12), or polypeptides comprising IL-12 or functional fragment of IL-12. Also provided herein are compositions, including lipid nanoparticles (LNPs), comprising the nucleic acid molecules, and related therapeutic methods and uses f...

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Bibliographische Detailangaben
Hauptverfasser:	XU, Xu, YING, Bo, ZHONG, Xia, JIANG, Yuhang, REN, Zhaoxiang, YAN, Huayuan
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are nucleic acid molecules encoding interleukin-12 (IL-12), or polypeptides comprising IL-12 or functional fragment of IL-12. Also provided herein are compositions, including lipid nanoparticles (LNPs), comprising the nucleic acid molecules, and related therapeutic methods and uses for the management or treatment of cancer in human. L'invention concerne des molécules d'acide nucléique codant pour l'interleukine-12 (IL-12), ou des polypeptides comprenant l'IL-12 ou un fragment fonctionnel d'IL-12. L'invention concerne également des compositions, comprenant des nanoparticules lipidiques (NPL), comprenant ces molécules d'acide nucléique, et des procédés thérapeutiques associés et des utilisations associées pour la gestion ou le traitement du cancer chez l'être humain.