[6R]-MTHF IN 5-FU BASED CHEMOTHERAPY OF RIGHT-SIDED COLORECTAL CANCER

The present invention relates to the treatment of right-sided colorectal cancer in human populations having a high frequency of poor prognostic factors, including BRAF- and KRAS mutations, which involves administering multiple boluses of [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF) in connection...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	LINDBERG, Per Lennart, TELL, Roger Ingvar, SKINTEMO, Lisa Katarina, HOLMÉN, Per Emil Jonathan
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention relates to the treatment of right-sided colorectal cancer in human populations having a high frequency of poor prognostic factors, including BRAF- and KRAS mutations, which involves administering multiple boluses of [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF) in connection with 5-fluorouracil (5-FU) based chemotherapy. La présente invention concerne le traitement du cancer colorectal côté droit chez des populations humaines ayant une haute fréquence de facteurs de pronostic médiocres, comprenant des mutations de BRAF et de KRAS , qui consiste à administrer de multiples bolus de [6R]-5,10-méthylènetétrahydrofolate ([6R]-MTHF) en liaison avec une chimiothérapie à base de 5-fluorouracile (5-FU).