[6R]-MTHF IN 5-FU BASED CHEMOTHERAPY OF BRAF- OR KRAS-MUTATED COLORECTAL CANCER

The present invention relates to the treatment of colorectal cancer in human populations having a high frequency of BRAF- or KRAS-mutations, which involves administering multiple boluses of [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF) in connection with 5-fluorouracil (5-FU) based chemotherapy. L...

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Hauptverfasser:	LINDBERG, Per Lennart, TELL, Roger Ingvar, SKINTEMO, Lisa Katarina, HOLMÉN, Per Emil Jonathan
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to the treatment of colorectal cancer in human populations having a high frequency of BRAF- or KRAS-mutations, which involves administering multiple boluses of [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF) in connection with 5-fluorouracil (5-FU) based chemotherapy. La présente invention concerne le traitement du cancer colorectal chez les populations humaines ayant une haute fréquence de mutations de BRAF- ou KRAS-, qui consiste à administrer de multiples bolus de [6R]-5,10-méthylènetétrahydrofolate ([6R]-MTHF) en liaison avec la chimiothérapie à base de 5-fluorouracile (5-FU).