SULFA KETONE COMPOUNDS, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF
The present invention relates to sulfa ketone compounds, a preparation method therefor, and a medical use thereof. In particular, the present invention relates to a sulfa ketone compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising same,...
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| creator | TIAN, Zhenhua YIN, Huijun YAN, Xu TIAN, Weixue JIA, Li HU, Yuandong WU, Guosheng CHANG, Jiang CHEN, Shizhu DENG, Wei YAO, Zhenhai HUO, Tao FU, Jianmin QIAN, Su XU, Shimin |
| description | The present invention relates to sulfa ketone compounds, a preparation method therefor, and a medical use thereof. In particular, the present invention relates to a sulfa ketone compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising same, and the use thereof as a Src homology region 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitor, in particular for the prevention or treatment of diseases associated with SHP2 activity. The definition of each group in general formula (I) is the same as in the description.
La présente invention concerne des composés de sulfan cétone, leur procédé de préparation et leur utilisation médicale. En particulier, la présente invention concerne un composé de sulfan cétone représenté par la formule générale (I), son procédé de préparation, une composition pharmaceutique le comprenant, et son utilisation en tant qu'inhibiteur de la phosphatase 2 de protéine tyrosine contenant le domaine de région d'homologie |
| format | Patent |
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La présente invention concerne des composés de sulfan cétone, leur procédé de préparation et leur utilisation médicale. En particulier, la présente invention concerne un composé de sulfan cétone représenté par la formule générale (I), son procédé de préparation, une composition pharmaceutique le comprenant, et son utilisation en tant qu'inhibiteur de la phosphatase 2 de protéine tyrosine contenant le domaine de région d'homologie</description><language>chi ; eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230330&DB=EPODOC&CC=WO&NR=2023046198A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25568,76551</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230330&DB=EPODOC&CC=WO&NR=2023046198A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TIAN, Zhenhua</creatorcontrib><creatorcontrib>YIN, Huijun</creatorcontrib><creatorcontrib>YAN, Xu</creatorcontrib><creatorcontrib>TIAN, Weixue</creatorcontrib><creatorcontrib>JIA, Li</creatorcontrib><creatorcontrib>HU, Yuandong</creatorcontrib><creatorcontrib>WU, Guosheng</creatorcontrib><creatorcontrib>CHANG, Jiang</creatorcontrib><creatorcontrib>CHEN, Shizhu</creatorcontrib><creatorcontrib>DENG, Wei</creatorcontrib><creatorcontrib>YAO, Zhenhai</creatorcontrib><creatorcontrib>HUO, Tao</creatorcontrib><creatorcontrib>FU, Jianmin</creatorcontrib><creatorcontrib>QIAN, Su</creatorcontrib><creatorcontrib>XU, Shimin</creatorcontrib><title>SULFA KETONE COMPOUNDS, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF</title><description>The present invention relates to sulfa ketone compounds, a preparation method therefor, and a medical use thereof. In particular, the present invention relates to a sulfa ketone compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising same, and the use thereof as a Src homology region 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitor, in particular for the prevention or treatment of diseases associated with SHP2 activity. The definition of each group in general formula (I) is the same as in the description.
La présente invention concerne des composés de sulfan cétone, leur procédé de préparation et leur utilisation médicale. En particulier, la présente invention concerne un composé de sulfan cétone représenté par la formule générale (I), son procédé de préparation, une composition pharmaceutique le comprenant, et son utilisation en tant qu'inhibiteur de la phosphatase 2 de protéine tyrosine contenant le domaine de région d'homologie</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAJDvVxc1Twdg3x93NVcPb3DfAP9XMJ1lEICHINcAxyDPH091PwdQ3x8HdRCPFwDXJ18w_SUXD0cwEKung6O_oohAa7QmT83XgYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXy4v5GBkbGBiZmhpYWjoTFxqgBmJS67</recordid><startdate>20230330</startdate><enddate>20230330</enddate><creator>TIAN, Zhenhua</creator><creator>YIN, Huijun</creator><creator>YAN, Xu</creator><creator>TIAN, Weixue</creator><creator>JIA, Li</creator><creator>HU, Yuandong</creator><creator>WU, Guosheng</creator><creator>CHANG, Jiang</creator><creator>CHEN, Shizhu</creator><creator>DENG, Wei</creator><creator>YAO, Zhenhai</creator><creator>HUO, Tao</creator><creator>FU, Jianmin</creator><creator>QIAN, Su</creator><creator>XU, Shimin</creator><scope>EVB</scope></search><sort><creationdate>20230330</creationdate><title>SULFA KETONE COMPOUNDS, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF</title><author>TIAN, Zhenhua ; YIN, Huijun ; YAN, Xu ; TIAN, Weixue ; JIA, Li ; HU, Yuandong ; WU, Guosheng ; CHANG, Jiang ; CHEN, Shizhu ; DENG, Wei ; YAO, Zhenhai ; HUO, Tao ; FU, Jianmin ; QIAN, Su ; XU, Shimin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023046198A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng ; fre</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>TIAN, Zhenhua</creatorcontrib><creatorcontrib>YIN, Huijun</creatorcontrib><creatorcontrib>YAN, Xu</creatorcontrib><creatorcontrib>TIAN, Weixue</creatorcontrib><creatorcontrib>JIA, Li</creatorcontrib><creatorcontrib>HU, Yuandong</creatorcontrib><creatorcontrib>WU, Guosheng</creatorcontrib><creatorcontrib>CHANG, Jiang</creatorcontrib><creatorcontrib>CHEN, Shizhu</creatorcontrib><creatorcontrib>DENG, Wei</creatorcontrib><creatorcontrib>YAO, Zhenhai</creatorcontrib><creatorcontrib>HUO, Tao</creatorcontrib><creatorcontrib>FU, Jianmin</creatorcontrib><creatorcontrib>QIAN, Su</creatorcontrib><creatorcontrib>XU, Shimin</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TIAN, Zhenhua</au><au>YIN, Huijun</au><au>YAN, Xu</au><au>TIAN, Weixue</au><au>JIA, Li</au><au>HU, Yuandong</au><au>WU, Guosheng</au><au>CHANG, Jiang</au><au>CHEN, Shizhu</au><au>DENG, Wei</au><au>YAO, Zhenhai</au><au>HUO, Tao</au><au>FU, Jianmin</au><au>QIAN, Su</au><au>XU, Shimin</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SULFA KETONE COMPOUNDS, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF</title><date>2023-03-30</date><risdate>2023</risdate><abstract>The present invention relates to sulfa ketone compounds, a preparation method therefor, and a medical use thereof. In particular, the present invention relates to a sulfa ketone compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising same, and the use thereof as a Src homology region 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitor, in particular for the prevention or treatment of diseases associated with SHP2 activity. The definition of each group in general formula (I) is the same as in the description.
La présente invention concerne des composés de sulfan cétone, leur procédé de préparation et leur utilisation médicale. En particulier, la présente invention concerne un composé de sulfan cétone représenté par la formule générale (I), son procédé de préparation, une composition pharmaceutique le comprenant, et son utilisation en tant qu'inhibiteur de la phosphatase 2 de protéine tyrosine contenant le domaine de région d'homologie</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SULFA KETONE COMPOUNDS, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF |
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