SULFA KETONE COMPOUNDS, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF

The present invention relates to sulfa ketone compounds, a preparation method therefor, and a medical use thereof. In particular, the present invention relates to a sulfa ketone compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising same,...

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Bibliographische Detailangaben
Hauptverfasser:	TIAN, Zhenhua, YIN, Huijun, YAN, Xu, TIAN, Weixue, JIA, Li, HU, Yuandong, WU, Guosheng, CHANG, Jiang, CHEN, Shizhu, DENG, Wei, YAO, Zhenhai, HUO, Tao, FU, Jianmin, QIAN, Su, XU, Shimin
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to sulfa ketone compounds, a preparation method therefor, and a medical use thereof. In particular, the present invention relates to a sulfa ketone compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising same, and the use thereof as a Src homology region 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitor, in particular for the prevention or treatment of diseases associated with SHP2 activity. The definition of each group in general formula (I) is the same as in the description. La présente invention concerne des composés de sulfan cétone, leur procédé de préparation et leur utilisation médicale. En particulier, la présente invention concerne un composé de sulfan cétone représenté par la formule générale (I), son procédé de préparation, une composition pharmaceutique le comprenant, et son utilisation en tant qu'inhibiteur de la phosphatase 2 de protéine tyrosine contenant le domaine de région d'homologie