NOVEL CATIONIC LIPID COMPOUND, PREPARATION METHOD THEREFOR, COMPOSITION AND APPLICATION THEREOF

Disclosed is a novel cationic lipid compound represented by formula (A), or an isomer, an N-oxide, a pharmaceutically acceptable salt, or a prodrug thereof. Further disclosed are a preparation method, a composition and an application of the described novel cationic lipid compound. The compound, as a...

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Bibliographische Detailangaben
Hauptverfasser:	DENG, Yonghua, HUANG, Caigu
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed is a novel cationic lipid compound represented by formula (A), or an isomer, an N-oxide, a pharmaceutically acceptable salt, or a prodrug thereof. Further disclosed are a preparation method, a composition and an application of the described novel cationic lipid compound. The compound, as a cationic lipid, is suitable for pharmaceutical compositions for nucleic acid delivery, and can achieve better stability, pKa value and intracellular drug delivery efficiency. Formula (A) is as follows: L'invention concerne un nouveau composé lipidique cationique représenté par la formule (A), ou un isomère, un N-oxyde, un sel pharmaceutiquement acceptable ou un promédicament de celui-ci. L'invention concerne en outre un procédé de préparation, une composition et une application du nouveau composé lipidique cationique décrit. Le composé, en tant que lipide cationique, est approprié pour des compositions pharmaceutiques pour l'administration d'acides nucléiques et permet d'obtenir des améliorations en termes de stab