ANTIBODIES AGAINST GPC3 AND USES THEREOF

Disclosed herein are antibodies against GPC3 and uses thereof, specifically monoclonal antibodies against GPC3, bispecific antibodies against GPC3 and CD3, nucleic acids comprising the antibodies, vectors comprising the nucleic acids, and host cell comprising the nucleic acids or the vectors. Also d...

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Bibliographische Detailangaben
Hauptverfasser:	WANG, Guannv, XIAO, Zuoxiang, PENG, Jiaping, ZHOU, Dongwen, ZHOU, Wei, MIAO, Hangbin
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are antibodies against GPC3 and uses thereof, specifically monoclonal antibodies against GPC3, bispecific antibodies against GPC3 and CD3, nucleic acids comprising the antibodies, vectors comprising the nucleic acids, and host cell comprising the nucleic acids or the vectors. Also disclosed are pharmaceutical compositions and conjugates comprising the antibodies, and therapeutic methods for using the antibodies. L'invention concerne des anticorps anti-GPC3 et leurs utilisations, plus précisément des anticorps monoclonaux anti-GPC3, des anticorps bispécifiques dirigés contre GPC3 et CD3, des acides nucléiques comprenant les anticorps, des vecteurs comprenant les acides nucléiques, et une cellule hôte comprenant les acides nucléiques ou les vecteurs. L'invention concerne également des compositions pharmaceutiques et des conjugués comprenant lesdits anticorps, et des procédés thérapeutiques pour utiliser lesdits anticorps.