COMPOSITIONS AND METHODS FOR TREATING BIOFILM DISORDERS AND INFECTION

The disclosure relates to organosulfur containing compositions, in particular Di-n-butyl thiosulfinate, Di-methyl thiosulfonate, Di -phenyl thiosulfonate, Bis (p-tolyl) thiosulfinate, Di-isopropyl thiosulfinate, Di-benzyl thiosulfinate, Di-benzyl thiosulfonate, S-propyl-4-methylbenzene thiosulfonate...

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Bibliographische Detailangaben
Hauptverfasser:	KHOKHAR, Shaista Sheroze, SCHUTTEVAAR, Anne Myrthe, STREEFLAND, Gerrit Jan, DE BOER, Lex, WRONSKA, Anna Kristina
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRAPPING
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Beschreibung
Zusammenfassung:	The disclosure relates to organosulfur containing compositions, in particular Di-n-butyl thiosulfinate, Di-methyl thiosulfonate, Di -phenyl thiosulfonate, Bis (p-tolyl) thiosulfinate, Di-isopropyl thiosulfinate, Di-benzyl thiosulfinate, Di-benzyl thiosulfonate, S-propyl-4-methylbenzene thiosulfonate, Di -n-propyl thiosulfinate, and Di-n-propyl thiosulfonate. Such compositions are useful for treating infection and reducing or degrading biofilms both in vivo and in vitro. In particular, such compositions are useful in the treatment of biofilm-related disorders, including but not limited to mastitis, digital dermatitis, and chronic wound infections. L'invention concerne des compositions contenant de l'organosoufré, en particulier le Di-n-butyl thiosulfinate, le Di-méthyl thiosulfonate, le Di-phényl thiosulfonate, le Bis (p-tolyl) thiosulfinate, le Di-isopropyl thiosulfinate, le Di-benzyl thiosulfinate, le Di-benzyl thiosulfonate, le S-propyl-4-méthylbenzène thiosulfonate, le Di-n-propyl thiosulfinate, et le Di-n-propyl thiosulfonate. De telles compositions sont utiles pour traiter une infection et réduire ou dégrader des biofilms à la fois in vivo et in vitro. En particulier, de telles compositions sont utiles dans le traitement de troubles liés à un biofilm, comprenant, mais sans s'y limiter, la mammite, la dermatite digitale, et les infections cutanées chroniques.