AN IMPROVED PROCESS FOR THE PREPARATION OF N-ETHYL- α -METHYL-3-(TRIFLUOROMETHYL)PHENETHYLAMINE HYDROCHLORIDE

AN IMPROVED PROCESS FOR THE PREPARATION OF N-ETHYL- α -METHYL-3-(TRIFLUOROMETHYL)PHENETHYLAMINE HYDROCHLORIDE

The present invention relates to an improved process for the preparation of N-ethyl- α -methyl-3-(trifluoromethyl) phenethylamine hydrochloride (1), having purity greater than 99.5% by HPLC using highly pure 3-(trifluoromethyl) aniline hydrochloride (5) as a key starting material. The present invent...

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Hauptverfasser: PULLAGURLA, Manik Reddy, PITTA, Bhaskar Reddy, RANGISETTY, Jagadeesh Babu
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:The present invention relates to an improved process for the preparation of N-ethyl- α -methyl-3-(trifluoromethyl) phenethylamine hydrochloride (1), having purity greater than 99.5% by HPLC using highly pure 3-(trifluoromethyl) aniline hydrochloride (5) as a key starting material. The present invention provides process for the purification of N-ethyl-α -methyl-3-(trifluoromethyl) phenethylamine hydrochloride (1), which is substantially free of Impurity A and Impurity B. La présente invention concerne un processus amélioré de préparation de chlorhydrate de N-éthyl-α-méthyl-3-(trifluorométhyl)phénéthylamine (1), ayant une pureté supérieure à 99,5 % par HPLC faisant appel à du chlorhydrate de 3-(trifluorométhyl)aniline (5) à pureté élevée en tant que matériau de départ clé. La présente invention concerne un processus de purification de chlorhydrate de N-éthyl-α-méthyl-3-(trifluorométhyl)phénéthylamine (1), qui est sensiblement exempt d'impuretés A et d'impuretés B (I)