INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS

The invention relates to heterocyclic compounds of formulae (I) and (II), pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR...

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Bibliographische Detailangaben
Hauptverfasser:	GILLESPY, Timothy, BORCHERDING, David, NIEDUZAK, Thaddeus, VAZ, Roy, LI, Yi, GAO, Zhongli, LIAO, Junkai, HURLBUT, Gregory, BARRAGUE, Matthieu, METZ, Markus, GROSS, Alexandre, GOOD, Andrew, HIRTH, Bradford, THURAIRATNAM, Sukanthini, RUVINSKY, Anatoly, LIU, Jinyu, MUNSON, Mark, KOTHE, Michael
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to heterocyclic compounds of formulae (I) and (II), pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis. L'invention concerne des composés hétérocycliques de formules (I) et (II), des sels pharmaceutiquement acceptables de ceux-ci, et des préparations pharmaceutiques de ceux-ci. L'invention concerne également des compositions et l'utilisation de tels composés dans des procédés de traitement de maladies et d'états pathologiques médiés par une activité de CFTR déficiente, en particulier la fibrose kystique.