METHOD FOR TREATING BLOOD PLASMA SAMPLE CONTAINING CLOPIDOGREL OXIDE, AND MEASUREMENT METHOD

Disclosed is a method for treating a blood plasma sample containing (7aS,2'S)-2-oxo-clopidogrel, and a measurement method, which belong to the technical field of pharmaceutical analysis, and solve the problem in the prior art whereby there is not yet a method for measuring the concentration of...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG, Hai, MOU, Xia
Format: Patent
Sprache:chi ; eng ; fre
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Zusammenfassung:Disclosed is a method for treating a blood plasma sample containing (7aS,2'S)-2-oxo-clopidogrel, and a measurement method, which belong to the technical field of pharmaceutical analysis, and solve the problem in the prior art whereby there is not yet a method for measuring the concentration of (7aS,2'S)-2-oxo-clopidogrel in blood plasma. The method for treating a blood plasma sample containing (7aS,2'S)-2-oxo-clopidogrel comprises: taking whole blood containing (7aS,2'S)-2-oxo-clopidogrel, adding a reducing agent solution to same, and collecting blood plasma to obtain a blood plasma sample. The method for measuring (7aS,2'S)-2-oxo-clopidogrel in blood plasma involves treating, by using the treatment method, a sample to be measured, and comprises the following steps: S1, treatment of whole blood, involving: taking whole blood, adding a reducing agent solution to same, centrifuging same, and collecting blood plasma; S2, pretreatment of a blood plasma sample, involving: adding a protein precipitant and an intern