INHIBITORS OF 12/15-LIPOXYGENASE

INHIBITORS OF 12/15-LIPOXYGENASE

The present application provides oxazoles-containing compounds, or a pharmaceutically acceptable salt thereof, that are 12/15-LOX inhibitors. Pharmaceutical compositions and methods of using these compounds for treating various conditions wherein 12/15-LOX is implicated (such as stroke) are also pro...

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Bibliographische Detailangaben
Hauptverfasser: HOLMAN, Theodore, HERR, Robert Jason, VAN LEYEN, Klaus, ZHENG, Yi, JOHNSON, Graham
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The present application provides oxazoles-containing compounds, or a pharmaceutically acceptable salt thereof, that are 12/15-LOX inhibitors. Pharmaceutical compositions and methods of using these compounds for treating various conditions wherein 12/15-LOX is implicated (such as stroke) are also provided. La présente invention concerne des composés contenant des oxazoles, ou un sel pharmaceutiquement acceptable de ceux-ci, qui sont des inhibiteurs de 12/15-LOX. L'invention concerne également des compositions pharmaceutiques et des procédés d'utilisation de ces composés pour traiter diverses affections dans lesquelles 12/15-LOX est impliqué (telles qu'un accident vasculaire cérébral).